Once I start diabetes tablets (meds), do I have to take them for lifelong ?
Patient's Query
I was recently diagnosed with diabetes. You started me on tablets. I’ve changed everything now I lost weight, stopped junk food, alcohol, smoking, I exercise daily, and my sugars are normal today.
So I’m confused. Once diabetes medicines are started, are they lifelong? Or can I stop them now that my sugars are normal? I keep hearing about ‘diabetes reversal’. Is that true?
Endocrinologist Answers

This is a very important question, and your confusion is completely valid.
Let’s clear it step by step.

First, an important truth
Normal sugar reports do NOT always mean diabetes is cured. Most of the time, it means the treatment and lifestyle changes are working.
Understanding diabetes in simple terms
Type 2 diabetes happens because of two main problems:
- Your body’s insulin does not work properly. (this is called insulin resistance - insulin is there, but it is not effective)
- Over time, insulin-producing cells in the pancreas become weaker. (these are called beta cells)
Different diabetes medicines work in different ways:
- Some help your body use insulin better.
- Some help your pancreas release insulin.
- Some help the body remove extra sugar through urine.
The final goal is simple: Keep blood sugar in a safe range to prevent complications
So… is diabetes medication lifelong?
The honest answer is: It depends on the stage of diabetes.
When diabetes medicines MAY be stopped
In early type 2 diabetes, especially when:
- Diagnosis is recent.
- Weight loss of around 10% or more is achieved.
- Lifestyle changes are strong and consistent.
- Only low doses of medicines are needed.
Some patients can enter diabetes remission. Important word here is REMISSION, not reversal.
Remission means:
- Sugars stay normal without medicines.
- But the tendency for diabetes still exists.
- Diabetes can return if lifestyle slips.
This is why we never advise stopping medicines on your own.
Why doctors avoid the word “reversal”
Because diabetes is not like an infection that disappears forever.
Think of it like:
- Blood pressure.
- Thyroid disease.
Early control can allow treatment reduction, but the condition can come back silently.
When diabetes medicines usually cannot be stopped
If:
- Diabetes duration is long (5-10 years or more).
- Higher doses or multiple medicines are required.
- Insulin has already been needed.
- Beta cell function has reduced significantly.
In these cases:
- Medicines are usually long-term.
- The focus is on good control, not stopping drugs.
And remember this key line:
“Well-controlled diabetes causes almost no damage”.
About tests like C-peptide
Some people hear about tests to “check insulin production”.
Important to know:
- These tests are not routine.
- Results can be misleading if sugars are very high.
- Interpretation needs specialist experience.
So please don’t self-order these tests.
What should YOU do practically?
- Never stop diabetes medicines on your own.
- Continue lifestyle changes - they are powerful.
- Monitor:
Fasting sugar
- Post-meal sugar
- HbA1c (every 3-6 months)
- Let your doctor decide:
Dose reduction
- Trial withdrawal (if appropriate)
- Restart if sugars rise again
Simple takeaway for patients
- Diabetes is usually a chronic condition.
- Early diabetes can sometimes go into remission.
- Remission is not permanent cure.
- Medicines protect you - they are not a failure.
- Doctor-guided decisions are key.
Final Reassurance:
If you’ve improved your lifestyle, you’ve already done the hardest part. Whether medicines are continued or reduced, you are winning as long as sugars stay controlled.
References:
Disclaimer: The information provided in this Q&A is for educational purposes only and should not be considered as medical advice. Always consult with a qualified healthcare professional for personalized medical guidance and treatment recommendations.